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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FEBUXOSTAT
| FEBUXOSTAT | METABOLISM | ORAL | Cmax 8.22 MICROMOLAR Tmax 1.25 HOUR F 49 PERCENT VD 50 LITER PPB 99.2 PERCENT Cl 5.3 LITER / HOUR (EQN) HT 6.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | XANTHINE OXIDASE PDB 1N5X (XANTHINE DEHYDROGENASE FROM BOVINE MILK WITH INHIBITOR TEI-6720 BOUND) LIGAND CODE = TEI (link to the list of PDB complexes) Download experimental 3D coordinates of TEI with added hydrogens | XANTHINE DEHYDROGENASE INHIBITOR CHEMBL1929 XANTHINE DEHYDROGENASE P47989 XANTHINE DEHYDROGENASE/OXIDASE HOMO SAPIENS ENZYME REDUCTASE | EMA | |||
