Cheminformatic Tools and Databases for Pharmacology

session 50156 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
OLANZAPINE

OLANZAPINE


ATC N05AH03

NERVOUS SYSTEM
ANTIPSYCHOTIC
TREATMENT OF SCHIZOPHRENIA
SEROTONIN 5HT-2A (KI=4 NANOMOLAR), 5HT-2C (KI=11 NANOMOLAR), 5HT-6 (KI=11 NANOMOLAR) ANTAGONIST
D(2) DOPAMINE RECEPTOR ANTAGONIST
DOPAMINE D1-4 (KI=11-31 NANOMOLAR)
HISTAMINE H1 (KI=7 NANOMOLAR)
ADRENERGIC ALPHA-1 RECEPTOR (KI=19 NANOMOLAR)
SEROTONIN 5HT-3 (KI=57 NANOMOLAR)
MUSCARINIC M1-5 (KI=32-132 NANOMOLAR)

 ORAL INTRAMUSCULAR

Tmax 6 HOUR

VD 1000 LITER

PPB 93 PERCENT

Cl 25 LITER / HOUR

HT 30 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5HT-2)
D(2) DOPAMINE RECEPTOR

 D2-LIKE DOPAMINE RECEPTOR ANTAGONIST CHEMBL2331075 D2-LIKE DOPAMINE RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTOREMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |