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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IRINOTECAN
| IRINOTECAN | ANTINEOPLASTIC | INJECTION INTRAVENOUS | Cmax 5.78 MICROMOLAR VD 376 LITER PPB 49 PERCENT Cl 22.3 LITER / HOUR HT 8 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | DNA TOPOISOMERASE I COMPLEX PDB 1U65 (ACHE W. CPT-11) LIGAND CODE = CP0 (link to the list of PDB complexes) Download experimental 3D coordinates of CP0 with added hydrogens | DNA TOPOISOMERASE I INHIBITOR CHEMBL1781 DNA TOPOISOMERASE I P11387 DNA TOPOISOMERASE 1 HOMO SAPIENS ENZYME ISOMERASE | EMA | |||
