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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PACLITAXEL
| PACLITAXEL | NATURAL MOLECULE (link) ANTINEOPLASTIC | INJECTION INTRAVENOUS | Cmax 4.3 MICROMOLAR VD 736 LITER PPB 93 PERCENT Cl 19.6 LITER / HOUR HT 20.2 HOUR SOLUBILITY INSOLUBLE IN WATER | TUBULIN PDB 4AQW (MODEL OF HUMAN KINESIN-5 MOTOR DOMAIN (1II6, 3HQD) AND MAMMALIAN TUBULIN HETERODIMER (1JFF) DOCKED INTO THE 9.5-ANGSTROM CRYO-EM MAP OF MICROTUBULE-BOUND KINESIN-5 MOTOR DOMAIN IN THE RIGOR STATE.) LIGAND CODE = TA1 (link to the list of PDB complexes) Download experimental 3D coordinates of TA1 with added hydrogens | TUBULIN INHIBITOR CHEMBL2095182 TUBULIN P04350 TUBULIN BETA-4A CHAIN HOMO SAPIENS STRUCTURAL | EMA | |||
