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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLADRIBINE (has an active metabolite)
| CLADRIBINE | ANTINEOPLASTIC | INJECTION ORAL | VD 292.5 LITER (65 KILOGRAM) PPB 20 PERCENT Cl 63.5 LITER / HOUR (65 KILOGRAM) HT 5.4 HOUR | DEOXYCYTIDINE KINASE PDB 2ZIA (C4S DCK VARIANT OF DCK IN COMPLEX WITH CLADRIBINE+UDP) LIGAND CODE = CL9 (link to the list of PDB complexes) Download experimental 3D coordinates of CL9 with added hydrogens | DNA INHIBITOR CHEMBL2311221 DNA HOMO SAPIENS | EMA | |||
