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INN

Class

Route (list)

PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)

Primary Target and PDB code of Protein-Drug complex

Targets from DrugCentral

Links

PROCARBAZINE

ATC L01XB01

ANTINEOPLASTIC
TREATMENT OF STAGE III AND IV HODGKIN'S DISEASE
MAY INHIBIT TRANSMETHYLATION OF METHYL GROUPS OF METHIONINE INTO T-RNA
HYDROGEN PEROXIDE FORMED DURING THE AUTO-OXIDATION OF THE DRUG MAY ATTACK PROTEIN SULFHYDRYL GROUPS CONTAINED IN RESIDUAL PROTEIN WHICH IS TIGHTLY BOUND TO DNA

ORAL

Tmax 1 HOUR

F 100 PERCENT

HT 0.16 HOUR

SOLUBILITY SOLUBLE BUT UNSTABLE IN WATER

DNA

DNA INHIBITOR CHEMBL2311221 DNA HOMO SAPIENS

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank