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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METYRAPONE
| METYRAPONE | VARIOUS | ORAL | Cmax 32.3 MICROMOLAR Tmax 1 HOUR HT 1.9 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | CYTOCHROME P450 CYP11B1 PDB 1W0G (CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4) LIGAND CODE = MYT (link to the list of PDB complexes) Download experimental 3D coordinates of MYT with added hydrogens | ENZYME C11B1_HUMAN INHIBITOR P15538 | EMA | |||
