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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COLCHICINE
| COLCHICINE | NATURAL MOLECULE (link) MUSCULO-SKELETAL | ORAL | Cmax 6.25 NANOMOLAR (0.6 MILLIGRAM) Tmax 1.5 HOUR F 45 PERCENT VD 341.5 LITER PPB 39 PERCENT Cl 54.1 LITER / HOUR HT 28.9 HOUR SOLUBILITY SOLUBLE IN WATER | TUBULIN PDB 4X1K (DISCOVERY OF CYTOTOXIC DOLASTATIN 10 ANALOGS WITH N-TERMINAL MODIFICATIONS) LIGAND CODE = LOC (link to the list of PDB complexes) Download experimental 3D coordinates of LOC with added hydrogens | TUBULIN INHIBITOR CHEMBL2095182 TUBULIN P04350 TUBULIN BETA-4A CHAIN HOMO SAPIENS STRUCTURAL | EMA | |||
