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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRIAMCINOLONE ACETONIDE
| TRIAMCINOLONE ACETONIDE | ANTIINFLAMMATORY | TOPICAL INJECTION DENTAL INHALATION NASAL INTRAVITREAL | Cmax 2.58 NANOMOLAR Tmax 0.5 HOUR VD 99.5 LITER PPB 68 PERCENT Cl 45.2 LITER / HOUR HT 1.46 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | GLUCOCORTICOID RECEPTOR PDB 5UFS (X-RAY CRYSTAL STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH TRIAMCINOLONE ACETONIDE AND SHP COREGULATOR FRAGMENT) LIGAND CODE = 1TA (link to the list of PDB complexes) Download experimental 3D coordinates of 1TA with added hydrogens | GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1 | EMA | |||
