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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AVUTOMETINIB
| AVUTOMETINIB | ANTINEOPLASTIC | ORAL | Tmax 2 HOUR VD 25 LITER PPB 99 PERCENT Cl 0.3 LITER / HOUR HT 51 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | MEK1 ERK1 PDB 3WIG (HUMAN MEK1 KINASE IN COMPLEX WITH CH5126766 AND MGAMP-PNP) LIGAND CODE = CHU (link to the list of PDB complexes) Download experimental 3D coordinates of CHU with added hydrogens | - more at DrugCentral | EMA | |||
