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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VIMSELTINIB
| VIMSELTINIB | CASS ANTINEOPLASTIC | ORAL | Cmax 1.7 MICROMOLAR Tmax 1 HOUR VD 90 LITER PPB 96.5 PERCENT Cl 0.5 LITER / HOUR HT 144 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | COLONY-STIMULATING FACTOR 1 RECEPTOR (CSF1R) PDB 7MFC (CRYSTAL STRUCTURE OF CSF1R IN COMPLEX WITH VIMSELTINIB) LIGAND CODE = Z6V (link to the list of PDB complexes) Download experimental 3D coordinates of Z6V with added hydrogens | - more at DrugCentral | EMA | |||
