| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| INAVOLISIB
| INAVOLISIB | ANTINEOPLASTIC | ORAL | Cmax 169.3 NANOMOLAR Tmax 3 HOUR F 76 PERCENT VD 155 LITER PPB 37 PERCENT Cl 8.8 LITER / HOUR HT 15 HOUR SOLUBILITY DECREASES WITH INCREASING PH | PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) ALPHA PDB 8EXV (CRYSTAL STRUCTURE OF PI3K-ALPHA IN COMPLEX WITH COMPOUND 32) LIGAND CODE = X3N (link to the list of PDB complexes) Download experimental 3D coordinates of X3N with added hydrogens | - more at DrugCentral | EMA | |||
