| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DELGOCITINIB
| DELGOCITINIB | DERMATOLOGICALS | TOPICAL | Cmax 4.9 NANOMOLAR PPB 25 PERCENT HT 21 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER AT PH 5.0 | JANUS KINASE JAK1 JAK2 JAK3 TYROSINE KINASE 2 (TYK2) PDB 7C3N (CRYSTAL STRUCTURE OF JAK3 IN COMPLEX WITH DELGOCITINIB) LIGAND CODE = FHX (link to the list of PDB complexes) Download experimental 3D coordinates of FHX with added hydrogens | Tyrosine-protein kinase JAK3 UNIPROT P52333 JAK3_HUMAN -- Non-receptor tyrosine-protein kinase TYK2 UNIPROT P29597 TYK2_HUMAN more at DrugCentral | EMA | |||
