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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VORASIDENIB
| VORASIDENIB | ANTINEOPLASTIC | ORAL | Cmax 320 NANOMOLAR Tmax 2 HOUR F 34 PERCENT VD 3930 LITER PPB 97 PERCENT Cl 14 LITER / HOUR HT 240 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | IDH1 IDH2 PDB 6VFZ (CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE (IDH2) R140Q MUTANT HOMODIMER IN COMPLEX WITH NADPH AND AG-881 (VORASIDENIB) INHIBITOR) LIGAND CODE = 9UO (link to the list of PDB complexes) Download experimental 3D coordinates of 9UO with added hydrogens | - more at DrugCentral | EMA | |||
