| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACORAMIDIS
| ACORAMIDIS | CARDIOVASCULAR | ORAL | Cmax 46.8 MICROMOLAR Tmax 1 HOUR VD 654 LITER PPB 96 PERCENT Cl 16 LITER / HOUR HT 6 HOUR SOLUBILITY 12 MICROGRAM PER MILLILITER | TRANSTHYRETIN (TTR) PDB 4HIQ (THE STRUCTURE OF V122I MUTANT TRANSTHYRETIN IN COMPLEX WITH AG10) LIGAND CODE = 16V (link to the list of PDB complexes) Download experimental 3D coordinates of 16V with added hydrogens | - more at DrugCentral | EMA | |||
