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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MIRDAMETINIB
| MIRDAMETINIB | ANTINEOPLASTIC | ORAL | Cmax 389 NANOMOLAR Tmax 0.8 HOUR VD 255 LITER PPB 99 PERCENT Cl 6.3 LITER / HOUR HT 28 HOUR SOLUBILITY 0.25 MILLIGRAM PER MILLILITER | MEK1 MEK2 ERK PDB 7JUU (CRYSTAL STRUCTURE OF KSR2:MEK1 IN COMPLEX WITH AMP-PNP, AND ALLOSTERIC MEK INHIBITOR PD0325901) LIGAND CODE = 4BM (link to the list of PDB complexes) Download experimental 3D coordinates of 4BM with added hydrogens | - more at DrugCentral | EMA | |||
