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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GEPOTIDACIN
| GEPOTIDACIN | ANTIINFECTIVES | ORAL | Cmax 9.36 MICROMOLAR F 45 PERCENT VD 172.9 LITER PPB 33 PERCENT Cl 33.4 LITER / HOUR HT 9.3 HOUR | TYPE II TOPOISOMERASE (DNA GYRASE) TOPOISOMERASE IV PDB 6QTK (2.31A STRUCTURE OF GEPOTIDACIN WITH S.AUREUS DNA GYRASE AND DOUBLY NICKED DNA) LIGAND CODE = JHN (link to the list of PDB complexes) Download experimental 3D coordinates of JHN with added hydrogens | - more at DrugCentral | EMA | |||
