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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACOLTREMON
| ACOLTREMON | SENSORY | OPHTHALMIC | Cmax 0.73 NANOMOLAR SOLUBILITY INSOLUBLE IN WATER | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) PDB 6NR2 (CRYO-EM STRUCTURE OF THE TRPM8 ION CHANNEL IN COMPLEX WITH THE MENTHOL ANALOG WS-12 AND PI(4,5)P2) LIGAND CODE = KXS (link to the list of PDB complexes) Download experimental 3D coordinates of KXS with added hydrogens | - more at DrugCentral | EMA | |||
