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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| XANOMELINE
| XANOMELINE | NERVOUS SYSTEM | ORAL | Tmax 2 HOUR VD 10800 LITER PPB 95 PERCENT Cl 1950 LITER / HOUR HT 5 HOUR SOLUBILITY HIGHLY SOLUBLE IN WATER | M1 MUSCARINIC ACETYLCHOLINE RECEPTORS M4 MUSCARINIC ACETYLCHOLINE RECEPTORS PDB 8FX5 (HUMAN M4 MUSCARINIC ACETYLCHOLINE RECEPTOR COMPLEX WITH GI1 AND XANOMELINE) LIGAND CODE = XNO (link to the list of PDB complexes) Download experimental 3D coordinates of XNO with added hydrogens | Muscarinic acetylcholine receptor M1 UNIPROT P11229 ACM1_HUMAN -- Muscarinic acetylcholine receptor M4 UNIPROT P08173 ACM4_HUMAN more at DrugCentral | EMA | |||
