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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CAPMATINIB

CAPMATINIB


ATC L01EX17

ANTINEOPLASTIC
TREATMENT OF METASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)
MET KINASE INHIBITOR

ORAL

Tmax 1.5 HOUR

F 70 PERCENT

VD 164 LITER

PPB 96 PERCENT

Cl 24 LITER / HOUR

HT 6.5 HOUR

SOLUBILITY LOW SOLUBILITY IN WATER

MET

Unknown - more at DrugCentralEMA

ANSM (in French)

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Chemical Probes Portal

ChEMBL
BindingDB
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