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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZANUBRUTINIB
| ZANUBRUTINIB | ANTINEOPLASTIC | ORAL | Cmax 1.15 MICROMOLAR Tmax 2 HOUR VD 881 LITER PPB 94 PERCENT Cl 182 LITER / HOUR HT 3 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE TO PRACTICALLY INSOLUBLE IN WATER | BRUTONS TYROSINE KINASE (BTK) PDB 6J6M (CO-CRYSTAL STRUCTURE OF BTK KINASE DOMAIN WITH ZANUBRUTINIB) LIGAND CODE = BA0 (link to the list of PDB complexes) Download experimental 3D coordinates of BA0 with added hydrogens | Tyrosine-protein kinase BTK INHIBITOR Q06187 (BTK_HUMAN) | EMA | |||
