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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SELINEXOR

SELINEXOR


ATC L01XX66

ANTINEOPLASTIC
NUCLEAR EXPORT EXPORTIN 1 (XPO1) INHIBITOR
IN COMBINATION WITH DEXAMETHASONE
TREATMENT OF REFRACTORY MULTIPLE MYELOMA (RRMM)

ORAL

Cmax 1.53 MICROMOLAR

Tmax 4 HOUR

VD 125 LITER

PPB 95 PERCENT

Cl 17.9 LITER / HOUR

HT 7 HOUR

EXPORTIN 1 (XPO1)

Exportin-1 INHIBITOR O14980 (XPO1_HUMAN)EMA

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