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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LEFAMULIN
| LEFAMULIN | ANTIINFECTIVES | ORAL INTRAVENOUS | Cmax 7 MICROMOLAR Tmax 1.4 HOUR F 25 PERCENT VD 86.1 LITER PPB 94.8 PERCENT Cl 11.9 LITER / HOUR HT 8 HOUR | RIBOSOMAL SUBUNIT 50S PDB 5HL7 (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LEFAMULIN) LIGAND CODE = 62B (link to the list of PDB complexes) Download experimental 3D coordinates of 62B with added hydrogens | 50S ribosomal protein inhibitor | EMA | |||
