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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DORAVIRINE
| DORAVIRINE | ANTIINFECTIVES | ORAL | Cmax 2.26 MICROMOLAR Tmax 2 HOUR F 64 PERCENT VD 60.5 LITER PPB 76 PERCENT Cl 6.36 LITER / HOUR HT 15 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | HIV-1 REVERSE TRANSCRIPTASE PDB 4NCG (HIV NON-NUCLEOSIDE REVERSE TRANSCRIPTASE) LIGAND CODE = 2KW (link to the list of PDB complexes) Download experimental 3D coordinates of 2KW with added hydrogens | Reverse transcriptase/RNaseH Q72547 | EMA | |||
