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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEZACAFTOR
| TEZACAFTOR | RESPIRATORY SYSTEM | ORAL | Cmax 11.4 MICROMOLAR Tmax 4 HOUR VD 271 LITER PPB 99 PERCENT Cl 1.31 LITER / HOUR HT 15 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | ION CHANNEL CFTR_HUMAN CHAPERONE P13569 | EMA | |||
