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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACALABRUTINIB
| ACALABRUTINIB | ANTINEOPLASTIC | ORAL | Cmax 694 NANOMOLAR Tmax 0.75 HOUR F 25 PERCENT VD 34 LITER PPB 97.5 PERCENT Cl 159 LITER / HOUR HT 0.9 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER AT PH VALUES ABOVE 6 | BRUTON TYROSINE KINASE (BTK) | KINASE BTK_HUMAN INHIBITOR Q06187 | EMA | |||
