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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OLAPARIB
| OLAPARIB | ANTINEOPLASTIC | ORAL | Tmax 2 HOUR VD 167 LITER PPB 82 PERCENT Cl 8.6 LITER / HOUR HT 11.9 HOUR SOLUBILITY PH-INDEPENDENT LOW SOLUBILITY OF APPROXIMATELY 0.1 MILLIGRAM / MILLILITER ACROSS THE PHYSIOLOGICAL PH RANGE | TANKYRASE 2 PDB 5DS3 (CRYSTAL STRUCTURE OF CONSTITUTIVELY ACTIVE PARP-1) LIGAND CODE = 09L (link to the list of PDB complexes) Download experimental 3D coordinates of 09L with added hydrogens | PARP 1, 2 & 3 INHIBITOR CHEMBL3390820 PARP 1, 2 AND 3 P09874 POLY [ADP-RIBOSE] POLYMERASE 1 HOMO SAPIENS ENZYME | EMA | |||
