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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| APREMILAST
| APREMILAST | ANTINEOPLASTIC AND IMMUNODULATING AGENT | ORAL | Tmax 2.5 HOUR F 73 PERCENT VD 87 LITER PPB 68 PERCENT Cl 10 LITER / HOUR HT 7.5 HOUR | PHOSPHODIEASTERASE 4 (PDE4) PDB 7CBQ (CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN IN COMPLEX WITH APREMILAST) LIGAND CODE = A9L (link to the list of PDB complexes) Download experimental 3D coordinates of A9L with added hydrogens | PHOSPHODIESTERASE 4 INHIBITOR CHEMBL2093863 PHOSPHODIESTERASE 4 P27815 CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_4 PDE_4A | EMA | |||
