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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SIMEPREVIR DISCONTINUED
| SIMEPREVIR | ANTIINFECTIVES | ORAL | Cmax 2.58 MICROMOLAR Tmax 5 HOUR F 62 PERCENT PPB 99.9 PERCENT HT 25.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | HEPATITIS C VIRUS (HCV) NS3/4A PROTEASE PDB 3KEE (HCV NS3/NS4A COMPLEXED WITH NON-COVALENT MACROCYCLIC COMPOUND TMC435) LIGAND CODE = 30B (link to the list of PDB complexes) Download experimental 3D coordinates of 30B with added hydrogens | HEPATITIS C VIRUS SERINE PROTEASE, NS3/NS4A INHIBITOR CHEMBL2095231 HEPATITIS C VIRUS SERINE PROTEASE, NS3/NS4A A3EZI9 NS3 HEPATITIS C VIRUS ENZYME PROTEASE SERINE PAS S29 | EMA | |||
