AFATINIB | AFATINIB | ATC L01XE13
ANTINEOPLASTIC TREATMENT OF METASTATIC NON-SMALL CELL LUNG CANCER TYROSINE KINASE INHIBITOR COVALENTLY BINDS TO THE KINASE DOMAINS OF EGFR (ERBB1), HER2 (ERBB2), AND HER4 (ERBB4) AND IRREVERSIBLY INHIBITS TYROSINE KINASE AUTOPHOSPHORYLATION, RESULTING IN DOWNREGULATION OF ERBB SIGNALING | ORAL | Tmax 3.5 HOUR F 92 PERCENT PPB 95 PERCENT HT 37 HOUR SOLUBILITY SOLUBLE IN WATER | EGFR (ERBB1) HER2 (ERBB2) HER4 (ERBB4) PDB 4G5J (CRYSTAL STRUCTURE OF EGFR KINASE IN COMPLEX WITH BIBW2992) LIGAND CODE = 0WM (link to the list of PDB complexes) Download experimental 3D coordinates of 0WM with added hydrogens | EPIDERMAL GROWTH FACTOR RECEPTOR ERBB1 INHIBITOR CHEMBL203 EPIDERMAL GROWTH FACTOR RECEPTOR ERBB1 P00533 EPIDERMAL GROWTH FACTOR RECEPTOR HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK EGFR | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |