PONATINIB | PONATINIB | ATC L01XE24
ANTINEOPLASTIC TYROSINE KINASE INHIBITOR ABL (IC50 = 0.4 NANOMOLAR) TREATMENT OF CHRONIC MYELOID LEUKEMIA (CML) VEGFR, PDGFR, FGFR, EPH RECEPTORS AND SRC FAMILIES OF KINASES AND KIT, RET, TIE2, AND FLT3 WITH IC50 CONCENTRATIONS BETWEEN 0.1 AND 20 NANOMOLAR | ORAL | Cmax 0.13 MICROMOLAR VD 1223 LITER PPB 99 PERCENT Cl 35.3 LITER / HOUR (EQN) HT 24 HOUR SOLUBILITY 0.16 MCG / MILLILITER AT PH 7 | ABL PDB 3ZOS (STRUCTURE OF THE DDR1 KINASE DOMAIN IN COMPLEX WITH PONATINIB) LIGAND CODE = 0LI (link to the list of PDB complexes) Download experimental 3D coordinates of 0LI with added hydrogens | TYROSINE-PROTEIN KINASE ABL INHIBITOR CHEMBL1862 TYROSINE-PROTEIN KINASE ABL P00519 TYROSINE-PROTEIN KINASE ABL1 HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK ABL | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |