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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COBICISTAT
| COBICISTAT |
ANTIINFECTIVES | ORAL | Cmax 1.4 MICROMOLAR Tmax 3 HOUR PPB 97 PERCENT HT 3.5 HOUR SOLUBILITY OF 0.1 MG PER ML | CYTOCHROME P450 3A | CYTOCHROME P450 3A INHIBITOR CHEMBL2364675 CYTOCHROME P450 3A P08684 CYTOCHROME P450 3A4 HOMO SAPIENS ENZYME CYTOCHROME P450 CYP_3 CYP_3A CYP_3A4 | EMA | |||
