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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ELVITEGRAVIR
| ELVITEGRAVIR |
ANTIINFECTIVES | ORAL | Cmax 3.8 MICROMOLAR Tmax 4 HOUR PPB 98 PERCENT HT 12.9 HOUR SOLUBILITY LESS THAN 0.3 MICROGRAMS PER ML IN WATER | VIRAL INTEGRASE PDB 3L2U (CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) INTASOME IN COMPLEX WITH MAGNESIUM AND GS9137 (ELVITEGRAVIR)) LIGAND CODE = ELV (link to the list of PDB complexes) Download experimental 3D coordinates of ELV with added hydrogens | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INTEGRASE INHIBITOR CHEMBL3471 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INTEGRASE Q7ZJM1 INTEGRASE HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME HYDROLASE | EMA | |||
