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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PERAMPANEL
| PERAMPANEL | NERVOUS SYSTEM | ORAL | VD 109 LITER (EQN) PPB 95 PERCENT Cl 0.72 LITER / HOUR HT 105 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | AMPA GLUTAMATE RECEPTOR PDB 5L1F (AMPA SUBTYPE IONOTROPIC GLUTAMATE RECEPTOR GLUA2 IN COMPLEX WITH NONCOMPETITIVE INHIBITOR PERAMPANEL) LIGAND CODE = 6ZP (link to the list of PDB complexes) Download experimental 3D coordinates of 6ZP with added hydrogens | GLUTAMATE RECEPTOR IONOTROPIC AMPA ANTAGONIST CHEMBL2096670 GLUTAMATE RECEPTOR IONOTROPIC AMPA P42261 GLUTAMATE RECEPTOR 1 HOMO SAPIENS ION CHANNEL LGIC GLUT AMPA | EMA | |||
