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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VISMODEGIB
| VISMODEGIB | ANTINEOPLASTIC AGENTS | ORAL | F 31.8 PERCENT (150 MILLIGRAM) VD 21.5 LITER (150 MILLIGRAM) PPB 99 PERCENT Cl 0.15 LITER / HOUR (EQN) HT 96 HOUR SOLUBILITY 0.1 MICROGRAM / MILLILITER AT PH 7 | SMOOTHENED TRANSMEMBRANE PROTEIN (IC50 = 7 NANOMOLAR) PMID22268551 PDB 5L7I (STRUCTURE OF HUMAN SMOOTHENED IN COMPLEX WITH VISMODEGIB) LIGAND CODE = VIS (link to the list of PDB complexes) Download experimental 3D coordinates of VIS with added hydrogens | SMOOTHENED HOMOLOG INHIBITOR CHEMBL5971 SMOOTHENED HOMOLOG Q99835 SMOOTHENED HOMOLOG HOMO SAPIENS MEMBRANE RECEPTOR 7TMFZ SMOOTHENED | EMA | |||
