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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IVACAFTOR
| IVACAFTOR |
RESPIRATORY SYSTEM | ORAL | Cmax 1.95 MICROMOLAR (150 MILLIGRAM) VD 353 LITER (150 MILLIGRAM EVERY 12 HOURS DURING 7 DAYS) PPB 99 PERCENT Cl 17.3 LITER / HOUR (150 MILLIGRAM) HT 12 HOUR (150 MILLIGRAM) SOLUBILITY PRACTICALLY INSOLUBLE IN WATER < 0.05 MICROGRAM / MILLILITER | G551D-CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PDB 6O2P (COMPLEX OF IVACAFTOR WITH CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)) LIGAND CODE = VX7 (link to the list of PDB complexes) Download experimental 3D coordinates of VX7 with added hydrogens | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR POSITIVE MODULATOR CHEMBL4051 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR P13569 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR HOMO SAPIENS ION CHANNEL OTHER CHLORIDE CFTR | EMA | |||
