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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VEMURAFENIB
| VEMURAFENIB | ANTINEOPLASTIC AGENT | ORAL | Cmax 126 MICROMOLAR (960 MILLIGRAM 15 DAYS) VD 106 LITER PPB 99 PERCENT Cl 1.3 LITER / HOUR HT 57 HOUR (960 MILLIGRAM) SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA | BRAF SERINE-THREONINE KINASE CRAF ARAF SRMS ACK1 MAP4K5 FGR PDB 5HES (HUMAN LEUCINE ZIPPER- AND STERILE ALPHA MOTIF-CONTAINING KINASE (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) IN COMPLEX WITH VEMURAFENIB) LIGAND CODE = 032 (link to the list of PDB complexes) Download experimental 3D coordinates of 032 with added hydrogens | SERINE/THREONINE-PROTEIN KINASE B-RAF INHIBITOR CHEMBL5145 SERINE/THREONINE-PROTEIN KINASE B-RAF P15056 SERINE/THREONINE-PROTEIN KINASE B-RAF HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TKL RAF | EMA | |||
