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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMBRISENTAN
| AMBRISENTAN | CARDIOVASCULAR | ORAL | VD 22 LITER (EQN) PPB 99 PERCENT Cl 1.71 LITER / HOUR HT 9 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | ENDOTHELIN TYPE-A RECEPTOR (ETA) (KI = 0.011 NANOMOLAR) | ENDOTHELIN RECEPTOR, ET-A/ET-B ANTAGONIST CHEMBL2096678 ENDOTHELIN RECEPTOR, ET-A/ET-B P24530 ENDOTHELIN B RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE ENDOTHELIN RECEPTOR | EMA | |||
