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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| KANAMYCIN DISCONTINUED
| KANAMYCIN | NATURAL MOLECULE (link)
ANTIINFECTIVES | ORAL INJECTION | VD 16.9 LITER (65 KILOGRAM) PPB 1 PERCENT Cl 5.4 LITER / HOUR (65 KILOGRAM) HT 2.1 HOUR | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB KANAMYCIN NUCLEOTIDYLTRANSFERASE PDB 4FEX (CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR TYRPHOSTIN AG1478) LIGAND CODE = KAN (link to the list of PDB complexes) Download experimental 3D coordinates of KAN with added hydrogens | BACTERIAL 70S RIBOSOME INHIBITOR CHEMBL2363135 BACTERIAL 70S RIBOSOME 16S RIBOSOMAL RNA BACTERIA | EMA | |||
