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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALISKIREN
| ALISKIREN |
CARDIOVASCULAR | ORAL | Tmax 2 HOUR F 2.5 PERCENT VD 135 LITER PPB 49 PERCENT Cl 9 LITER / HOUR HT 24 HOUR SOLUBILITY HIGHLY SOLUBLE IN WATER | RENIN PDB 2V0Z (CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 10 (ALISKIREN)) LIGAND CODE = C41 (link to the list of PDB complexes) Download experimental 3D coordinates of C41 with added hydrogens | RENIN INHIBITOR CHEMBL286 RENIN P00797 RENIN HOMO SAPIENS ENZYME PROTEASE ASPARTIC AA A1A | EMA | |||
