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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RASAGILINE
| RASAGILINE | NERVOUS SYSTEM | ORAL | F 36 PERCENT VD 87 LITER PPB 91 PERCENT Cl 20 LITER / HOUR (EQN) HT 3 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | MONOAMINE OXIDASE TYPE A (MAO-A) MONOAMINE OXIDASE TYPE B (MAO-B) APOPTOSIS REGULATOR BCL-2 AMINE OXIDASE [FLAVIN-CONTAINING] B PDB 2C75 (FUNCTIONAL ROLE OF THE AROMATIC CAGE IN HUMAN MONOAMINE OXIDASE B: STRUCTURES AND CATALYTIC PROPERTIES OF TYR435 MUTANT PROTEINS) LIGAND CODE = RSA (link to the list of PDB complexes) Download experimental 3D coordinates of RSA with added hydrogens | MONOAMINE OXIDASE B INHIBITOR CHEMBL2039 MONOAMINE OXIDASE B P27338 AMINE OXIDASE [FLAVIN-CONTAINING] B HOMO SAPIENS ENZYME REDUCTASE | EMA | |||
