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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PENTAMIDINE
| PENTAMIDINE | ANTIPARASITIC | INJECTION INHALATION | Cmax 1.8 MICROMOLAR (IV 4 MILLIGRAM / KILOGRAM) VD 3445 LITER (65 KILOGRAM) Cl 248 LITER / HOUR HT 25 HOUR SOLUBILITY SOLUBLE IN WATER | DNA-BINDING PROTEIN S100-B TRANSCRIPTIONAL REGULATOR QACR PDB 1RKW (CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE) LIGAND CODE = PNT (link to the list of PDB complexes) Download experimental 3D coordinates of PNT with added hydrogens | DNA INHIBITOR CHEMBL2366046 DNA PNEUMOCYSTIS JIROVECII | EMA | |||
