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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PYRIMETHAMINE
| PYRIMETHAMINE |
ANTIPARASITIC | ORAL | Cmax 805 NANOMOLAR Tmax 4 HOUR VD 149.5 LITER (65 KILOGRAM) PPB 90 PERCENT Cl 0.2 LITER / HOUR (65 KILOGRAM) HT 100 HOUR | DIHYDROFOLATE REDUCTASE PDB 4KM0 (CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PYRIMETHAMINE) LIGAND CODE = CP6 (link to the list of PDB complexes) Download experimental 3D coordinates of CP6 with added hydrogens | DIHYDROFOLATE REDUCTASE INHIBITOR CHEMBL1939 DIHYDROFOLATE REDUCTASE P13922 BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE PLASMODIUM FALCIPARUM K1 ENZYME REDUCTASE | EMA | |||
