| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ILOPROST
| ILOPROST | BLOOD | INHALATION | Cmax NOT DETECTABLE (PICOMOLAR) VD 24 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 62 LITER / HOUR (65 KILOGRAM) HT 0.57 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN DISTILLED WATER BUFFER PH 5 | PROSTACYCLIN RECEPTOR PGI2 PDB 3SP6 (STRUCTURAL BASIS FOR ILOPROST AS A DUAL PPARALPHA/DELTA AGONIST) LIGAND CODE = IL2 (link to the list of PDB complexes) Download experimental 3D coordinates of IL2 with added hydrogens | PROSTANOID IP RECEPTOR AGONIST CHEMBL1995 PROSTANOID IP RECEPTOR P43119 PROSTACYCLIN RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR PROSTANOID RECEPTOR | EMA | |||
