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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHADONE
| METHADONE | NERVOUS SYSTEM | ORAL INJECTION | Cmax 2.03 MICROMOLAR F 68 PERCENT VD 286 LITER (65 KILOGRAM) PPB 79 PERCENT Cl 6.6 LITER / HOUR (65 KILOGRAM) HT 31 HOUR SOLUBILITY VERY SOLUBLE IN WATER | MU-TYPE OPIOID RECEPTOR N-METHYL-D-ASPARTATE RECEPTOR (NMDA) | MU OPIOID RECEPTOR AGONIST CHEMBL233 MU OPIOID RECEPTOR P35372 MU-TYPE OPIOID RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE OPIOID RECEPTOR | EMA | |||
