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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CYCLOSERINE
| CYCLOSERINE | NATURAL MOLECULE (link) ANTIINFECTIVES | ORAL | Tmax 6 HOUR HT 12 HOUR SOLUBILITY SOLUBLE IN WATER | NMDA RECEPTOR D-ALANINE-D-ALANINE LIGASE ALANINE RACEMASE PDB 1PB9 (CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION) LIGAND CODE = 4AX (link to the list of PDB complexes) Download experimental 3D coordinates of 4AX with added hydrogens | D-ALANINE | EMA | |||
