e-Drug3D

923

CICLESONIDE

INN
CICLESONIDE

(has an active metabolite)

cas 126544-47-6

CLASS

RESPIRATORY
ANTIINFLAMMATORY
ANTI-ALLERGIC AGENTS
GLUCOCORTICOIDS

ROUTE (list)

INHALATION NASAL

ATC code

R01AD13
R03BA08

PK parameters

F 22 PERCENT
VD 188 LITER (65 KILOGRAM)
Cl 152 LITER / HOUR
PPB 99 PERCENT
t1/2 0.71 HOUR

Target

TARGET CORTICOSTEROID-BINDING GLOBULIN

DrugCentral

Glucocorticoid receptor UNIPROT P04150 NR3C1

Download SDF file

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11.beta.,16.alpha.)-

Formula:
C32H44O7

Calculated chemical properties:

MW 540.67
NB_atoms 39
XLogP 4.70
PSA 86.953
NB_HD 1
NB_HA 7
fsp3 0.78
Lipinski(0=no;1=yes) 0

FDA
NDA 022004 (label) INN (CICLESONIDE) OMNARIS (AZURITY) APPROVAL= AP YEAR= 2006 NEWMOLECULARENTITY
NDA 022124 (label) INN (CICLESONIDE) OMNARIS (NYCOMED US INC) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 021658 (label) INN (CICLESONIDE) ALVESCO (AZURITY) APPROVAL= AP YEAR= 2008
NDA 202129 (label) INN (CICLESONIDE) ZETONNA (AZURITY) APPROVAL= AP YEAR= 2012 DISCONTINUED