e-Drug3D

6
DESOXYCORTICOSTERONE PIVALATE

DISCONTINUED


INN
DESOXYCORTICOSTERONE PIVALATE

(has an active metabolite)

cas 808-48-0
CLASS

HORMONES
ANTI-ADDISON AGENTS
ADRENOCORTICAL STEROID
PRECURSOR OF ALDOSTERONE
SUBSTRATE OF ALDOSTERONE SYNTHASE (CYTOCHROME P450 CYP11B2)
ROUTE (list)

INJECTION

ATC code

H02AA03
PK parameters

Solubility

INSOLUBLE IN WATER


 Target

TARGET ALDOSTERONE SYNTHASE

PDB
4DVQ (HUMAN ALDOSTERONE SYNTHASE PMID23322723)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

 DrugCentral

Mineralocorticoid receptor UNIPROT P08235 NR3C2

 Download SDF file [2-(10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] 2,2-dimethylpropanoate

Formula:
C26H38O4

Calculated chemical properties:

MW 414.56
NB_atoms 30
XLogP 5.29
PSA 58.388
NB_HD 0
NB_HA 4
fsp3 0.81
Lipinski(0=no;1=yes) 0

FDA
NDA 008822 (pdf not found) INN (DESOXYCORTICOSTERONE PIVALATE) PERCORTEN (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL