e-Drug3D

295

THIOGUANINE

INN
THIOGUANINE

cas 154-42-7

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
TREATMENT OF ACUTE NONLYMPHOCYTIC LEUKEMIAS
THIOGUANINE IS INCORPORATED INTO THE DNA AND THE RNA OF HUMAN BONE MARROW CELLS

ROUTE (list)

ORAL

NATURAL MOLECULE (link)

ATC code

L01BB03

PK parameters

F 30 PERCENT
Tmax 8 HOUR
t1/2 5.9 HOUR

Target

TARGET HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRTASE)

DrugCentral

Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1

Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2

Download SDF file

2-amino-3,7-dihydropurine-6-thione

Formula:
C5H5N5S

Calculated chemical properties:

MW 167.21
NB_atoms 11
XLogP 0.60
PSA 73.212
NB_HD 4
NB_HA 5
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 012429 (label) INN (THIOGUANINE) THIOGUANINE (WAYLIS THERAP) APPROVAL= AP YEAR= 1966