e-Drug3D

22

cas 537-46-2

CLASS

NERVOUS SYSTEM
SYMPATHOMIMETIC AMINE
PSYCHOSTIMULANTS
TREATMENT OF ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY
TREATMENT OF EXOGENOUS OBESITY
LEADS TO THE FORMATION OF REACTIVE OXYGEN SPECIES IN THE BRAIN

ROUTE (list)

ORAL

PK parameters

F 67.2 PERCENT (PMID8104133)
VD 242 LITER (65 KILOGRAM)
Cl 17.1 LITER / HOUR (65 KILOGRAM)
PPB 15 PERCENT
t1/2 12.2 HOUR

TARGET DOPAMINE TRANSPORTER (DAT)
SEROTONINE TRANSPORTER

PDB
4XP6 (X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT METHAMPHETAMINE)

Ligand code = B40 (link to the list of PDB complexes)

Download experimental 3D coordinates of B40 with added hydrogens

MW 149.23
NB_atoms 11
XLogP 1.84
PSA 12.207
NB_HD 1
NB_HA 1
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 083889 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPEX (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086359 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (TEVA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 005378 (label) INN (METHAMPHETAMINE HYDROCHLORIDE) DESOXYN (AJENAT PHARMS) APPROVAL= AP YEAR= 1943
NDA 084931 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (REXAR) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 040529 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (ABLE) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 091189 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2010
NDA 203846 (pdf not found) INN (METHAMPHETAMINE HYDROCHLORIDE) METHAMPHETAMINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2015